We are developing a handheld enabled medication compliance management system (MCMS) using our FDA approved, HIPAA compliant handheld technology, MedStar. A handheld medication dispenser is developed to disallow any falsification of medication compliance data currently done through MEMS caps. This includes recording of medication compliance only after removing medication and in some cases ingestion of medication. It also aids the patient in adhering to the medication regimen by reminders and dispensing all the pills for a dosage. Additionally, using MedStar technology MCMS is able to transmit medication compliance data in real-time over a plain old telephone line.